Thursday, 6 September 2018

Now Treat Cartilage Degeneration With Your Own Blood Platelets

Platelet-rich plasma therapy (PRP) attempts to take advantage of the blood's natural healing properties and help in the revival of cartilage to improve function and thereby reducing pain.  The arrival of orthobiologicals like PRP and stem cells are used to achieve great results in case of ruptured muscles, damaged ligaments, and tendons as well as in non- healing fractures. Although the application of PRP has been around for decades, the treatment has become a more holistic kind of option in Osteoarthritis recently as PRP therapy repairs degenerative joints using your own healing growth factors.

People turning to PRP injections to treat an intensifying list of orthopaedic conditions, including osteoarthritis are escalating nowadays. PRP injections have been gaining popularity for a number of applications in orthopaedic surgery as a way to augment both healings of various tissues and decrease pain.  It is most frequently used for knee osteoarthritis, but may be used on other joints as well. The effect of Platelet concentrates on stem cells and chondrocytes has become the major area of focus. The potential for PRP to enhance cartilage regeneration and in the reduction of catabolic factors that lead to cartilage degradation has been well studied recently.


How is PRP therapy done?

  • PRP therapy is like the kickoff in a soccer game. It initiates the curative cascade into the local tissue. Nothing in the body heals without inflammation…absolutely nothing!
  • Your blood platelets play a vital role in blood clotting and injury/wound healing. The preparation and procedure of healing doses of growth factors consisting of a blood from the patient (autologous blood collection) and then placing it in a Centrifuge machine which extracts the Platelet-rich plasma (PRP) constituent from the blood.
  • The sample constitutes of platelets (blood cells) which consist of copious healing and inflammatory chemicals. This PRP sample is injected in the affected area under sterile precautions. This decreases inflammation and promotes healing.
  • In general, patients are treated every 3-6 weeks. Typically three to six visits are essential per region in the body.


Growth and healing factors in PRP?

Few years ago researchers at the University of Florence have established the remedial and repair factors found in platelet concentrates. There are many studies and clinical evidence which support the healing factors in PRP.
  • PDGF (Platelet-derived Growth Factor) initiates connective tissue healing through the promotion of collagen, glycosaminoglycan, and collagenase production by fibroblasts.
  • The most important effect of PDGF seems to be its mitogenesis of mesoderm-derived cells, better extracellular matrix synthesis, and chemotaxis and activation of monocytes, neutrophils, and fibroblasts.
  • Platelet-derived growth factor (PDGF)also plays a major role in inducing phenotypic switching from contractile to proliferative state vascular smooth muscle cells (VSMC’s)
  • The formation of fibrocartilage, cartilaginous and bony calluses is vital for bone healing.
  • The most important specific activity of PDGF is in articular cartilage repair

  • VEGF (Vascular Endothelial Growth Factor) also known as vascular permeability factor (the platelet-derived growth factor family of cystine-knot growth factors) is the chief regulator of angiogenesis and vasculogenesis. This plays an important role in tissue regeneration by generating new pathways of blood vessels for the therapeutic factors to get to the location of the injury.
  • Transforming Growth Factor (TGF) including TGF-b1 stimulates the rate of chondrocyte maturation and decreases the breakdown of cartilage. TGF- beta-mediated signaling pathways and their effects significantly impact the diagnosis and treatment of many common orthopaedic diseases.
The Chennai-based Trauma & Orthopaedic Speciality Hospital (TOSH), an exclusive orthopaedic hospital with international standards has now become one of the renowned Orthopaedic Care Centres in South India. The center offers the entire spectrum of services in trauma and orthopaedics, and also specialize in PRP stem cell therapy in Chennai, trauma surgery and limb reconstruction, PRP treatment for cartilage degeneration and joint restoration, spine surgery, hand surgery, paediatric orthopaedics, arthroscopic surgery, daycare Ortho surgery etc. They are the first ever healthcare unit in the country to launch stem cell and regenerative medicine unit in orthopaedics with a dedicated exclusive operation theatre for stem cell procedures. With world-class facility at affordable cost in all orthopaedic Sub-specialty, the hospital is committed to provide good quality orthopaedic and trauma care to patients from simple fracture treatment to sophisticated joint replacement and arthroscopic procedures.
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