Thursday, 6 September 2018

Now Treat Cartilage Degeneration With Your Own Blood Platelets

Platelet-rich plasma therapy (PRP) attempts to take advantage of the blood's natural healing properties and help in the revival of cartilage to improve function and thereby reducing pain.  The arrival of orthobiologicals like PRP and stem cells are used to achieve great results in case of ruptured muscles, damaged ligaments, and tendons as well as in non- healing fractures. Although the application of PRP has been around for decades, the treatment has become a more holistic kind of option in Osteoarthritis recently as PRP therapy repairs degenerative joints using your own healing growth factors. 

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People turning to PRP injections to treat an intensifying list of orthopaedic conditions, including osteoarthritis are escalating nowadays. PRP injections have been gaining popularity for a number of applications in orthopaedic surgery as a way to augment both healings of various tissues and decrease pain.  It is most frequently used for knee osteoarthritis, but may be used on other joints as well. The effect of Platelet concentrates on stem cells and chondrocytes has become the major area of focus. The potential for PRP to enhance cartilage regeneration and in the reduction of catabolic factors that lead to cartilage degradation has been well studied recently.

 

How is PRP therapy done?

  • PRP therapy is like the kickoff in a soccer game. It initiates the curative cascade into the local tissue. Nothing in the body heals without inflammation…absolutely nothing!
  • Your blood platelets play a vital role in blood clotting and injury/wound healing. The preparation and procedure of healing doses of growth factors consisting of a blood from the patient (autologous blood collection) and then placing it in a Centrifuge machine which extracts the Platelet-rich plasma (PRP) constituent from the blood.
  • The sample constitutes of platelets (blood cells) which consist of copious healing and inflammatory chemicals. This PRP sample is injected in the affected area under sterile precautions. This decreases inflammation and promotes healing.
  • In general, patients are treated every 3-6 weeks. Typically three to six visits are essential per region in the body.

 

Growth and healing factors in PRP?


Few years ago researchers at the University of Florence have established the remedial and repair factors found in platelet concentrates. There are many studies and clinical evidence which support the healing factors in PRP.
  • PDGF (Platelet-derived Growth Factor) initiates connective tissue healing through the promotion of collagen, glycosaminoglycan, and collagenase production by fibroblasts.
  • The most important effect of PDGF seems to be its mitogenesis of mesoderm-derived cells, better extracellular matrix synthesis, and chemotaxis and activation of monocytes, neutrophils, and fibroblasts.
  • Platelet-derived growth factor (PDGF)also plays a major role in inducing phenotypic switching from contractile to proliferative state vascular smooth muscle cells (VSMC’s)
  • The formation of fibrocartilage, cartilaginous and bony calluses is vital for bone healing.
  • The most important specific activity of PDGF is in articular cartilage repair
http://toshhospitals.com/stem-cell-therapy/prp/

  • VEGF (Vascular Endothelial Growth Factor) also known as vascular permeability factor (the platelet-derived growth factor family of cystine-knot growth factors) is the chief regulator of angiogenesis and vasculogenesis. This plays an important role in tissue regeneration by generating new pathways of blood vessels for the therapeutic factors to get to the location of the injury.
  • Transforming Growth Factor (TGF) including TGF-b1 stimulates the rate of chondrocyte maturation and decreases the breakdown of cartilage. TGF- beta-mediated signaling pathways and their effects significantly impact the diagnosis and treatment of many common orthopaedic diseases.
The Chennai-based Trauma & Orthopaedic Speciality Hospital (TOSH), an exclusive orthopaedic hospital with international standards has now become one of the renowned Orthopaedic Care Centres in South India. The center offers the entire spectrum of services in trauma and orthopaedics, and also specialize in PRP stem cell therapy in Chennai, trauma surgery and limb reconstruction, PRP treatment for cartilage degeneration and joint restoration, spine surgery, hand surgery, paediatric orthopaedics, arthroscopic surgery, daycare Ortho surgery etc. They are the first ever healthcare unit in the country to launch stem cell and regenerative medicine unit in orthopaedics with a dedicated exclusive operation theatre for stem cell procedures. With world-class facility at affordable cost in all orthopaedic Sub-specialty, the hospital is committed to provide good quality orthopaedic and trauma care to patients from simple fracture treatment to sophisticated joint replacement and arthroscopic procedures.
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Sunday, 26 August 2018

Stemcell Knee Cartilage Regeneration - An Alternate treatment for Knee Arthritis

A revolutionary new approach in the field of medicine has recently come to fruition with the introduction of Stem Cell Knee Cartilage Regeneration technique. In layman’s terms, stem cells isolated and extracted from the bone marrow is then introduced in damaged areas of the body to help the cells to multiply and the body to heal itself.

knee cartilage regeneration chennai

Stem Cell harvest and application is gaining distinctive inroads into all forms of therapeutic procedures, especially in the field of Orthopaedics, for the treatment of Knee Pain. Knee Pain, on account of osteoarthritis, caused due to debilitating effect of age is one of the prime causes of pain and agony to the patients. Conservative treatments initiate with pain relieving medication, physiotherapy, progress to steroid laced injections and ultimately calls for surgical intervention.

However, in most cases the patient does not report significant improvement in pain alleviation and is hence advised to undergo Knee Joint Replacement Surgery.

Stem Cell therapy for knees, is a minimally invasive procedure that can result in phenomenal decrease in pain and inflammation, check further arthritic damage, restore the joint cartilage and cause delay or render surgery superfluous.

The Knee-Worthy Stem Cell Cartilage Regeneration Procedure

The primary purpose of the joint cartilage at the knee is to allow for smooth gliding of the joint surfaces and protect the surrounding bone from further damage. The Articular Cartilage has the potential to act as a shock absorber and hold up to 20 times the body weight. However, with the onset of osteoarthritis, either caused due to age or previous trauma there is gradual degeneration of this joint cartilage. This leads to acute pain due to friction and subsequently damages to the bone beneath the cartilage and the associated ligaments, tendons and muscles causing restriction in mobility.

A Note on the Stem Cells Extracted?

Adult Stem Cells have been tested to have the potential to multiply into cartilage, bone, fat or soft tissue. It has been found in this context that the injection of progenitor cells, especially the Mesenchymal Stem Cell restore degenerative cartilage far better than differentiated cells. They respond best to areas of inflammation and degeneration and cause modification to the immune system to contribute to the surrounding cartilage in affected areas.

knee cartilage regeneration chennai

How Stem Cell Treatment is Initiated

Stem Cells are present in abundance in the umbilical cord and small children. In adults they are localised in the hip and chest bones from where they are extracted using BMAC, a minimally invasive procedure. The same is then isolated using a special machine and the subsequently isolated stem cells are introduced in the damaged area through injection of two kinds:

1. PRP – Platelet rich Plasma
2. BMAC – Bone Marrow aspirate concentrate

The therapeutic use of these particular Stem Cells has been found to be perfectly safe and effective in the treatment of knee cartilage pain and osteoarthritis. Many patients have outlasted the need for any surgical intervention as a result of advanced Stem Cell therapy.

Knee cartilage Regeneration in Chennai


Contact TOSH (Trauma and Orthopaedic Speciality Hospital at Chennai) to find out more about this innovative treatment and gain the welcome support of the renowned orthopaedic specialists in Chennai
contact us
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Monday, 26 February 2018

Live Straight With Scoliosis Correction Surgery

What is Scoliosis?

Scoliosis is an abnormal curvature of the spine. The spinal curve may develop as a single curve (like C) or two curves (like S). Scoliosis condition does not give any significant symptoms in teens and children until the condition has progressed. Idiopathic and degenerative scoliosis are the most common types. There are three orthopedic options for treating scoliosis are observation, bracing or surgical intervention. When the first two options fail to improve the condition, Scoliosis Correction Surgery will be the last option.
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Scoliosis Correction Surgery   

Spinal fusion is a surgical procedure in which the curved vertebrae are fused together. Then, the fused bones start to heal into a single and solid bone. This surgical method stops the growth in the abnormal spine segment and prevents the curve from getting worse. The spinal fusion is primarily used to reduce pain due to the abnormal vertebrae movement. Pain is diminished by stopping the movement of faulty vertebrae. Spinal fusion helps to treat many spinal deformities and scoliosis in one among them.
In the spinal fusion, a bone graft is done to promote the fusion. Generally, small bone pieces are placed into the spaces between vertebrae which have to be fused. Then, the bone starts to grow together.
Until the surgery ends, metal rods are used to hold the spine in place. With the help of hook, screw or wire the rods are attached to the spine. Normally from 4-8 hours is taken for the spinal fusion surgery and depends on the curve size, the time duration extends.
http://toshhospitals.com/spine-surgery/spinal-fusion/

Post-surgery

The hospital stay for the patient after the spinal fusion may be for 2-4 days. After the surgery, in the first few weeks, the patient is suggested with some basic exercises such as normal walking with a protective brace and few stretching exercises. Recovery may take from weeks to months depends on the patient condition.
TOSH (Trauma and Orthopedic Specialty Hospital) is one of the best orthopedic hospital in Chennai. The world-class treatment is offered by the expert and the best orthopedic specialists and it provides the best spinal surgery Chennai.
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